Heart failure & cardiomyopathies
Rising Arterial Stiffness with Accumulating Comorbidities Associates with Heart Failure with Preserved Ejection Fraction
Authors' conclusion
This study adds further support to the concept of HFpEF as a disease of the vasculature, underlined by an increasing arterial stiffness that is driven by vascular ageing and accumulating vascular comorbidities, for example, hypertension and diabetes.
Study context
- Population
- Patients aged 70 and above
- Participants
- 21 / 21 / 20 / 21 / 11
- Exposure
- Pulse wave velocity (PWV) across healthy volunteers, hypertension, hypertension + DM, heart failure with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF)
- Group An = 21reference
- Group Bn = 21
- Group Cn = 20
- Group Dn = 21
- Group En = 11
- Outcome
- Arterial stiffness by PWV
Main finding
As reported in the abstract
Mean PWV rose from Groups A to D (healthy, hypertension, hypertension + DM, HFpEF) as vascular comorbidities accumulated, independent of age, renal function, haemoglobin, BMI, smoking and hypercholesterolaemia
10.2, 12.2, 13.0, and 13.7 m/s, respectively
Observational data: associations, not effects.
Further findings
Correlation of PWV with peak oxygen consumption
- Inverse correlation, r
- −0.304
- P
- P = 0.03
Correlation of PWV with LV filling pressures (E/e') on echocardiography
- Positive correlation (as stated), r
- −0.307
- P
- P = 0.014
Original publication
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