Heart failure & cardiomyopathies
The plasma proteome is linked with left ventricular and left atrial function parameters in patients with chronic heart failure
Authors' conclusion
Circulating proteins show varying associations with different echocardiographic parameters in patients with HFrEF. These findings suggest that pathways involved in atrial and ventricular dysfunction, as reflected by the plasma proteome, are distinct.
Study context
- Population
- Patients with heart failure with reduced ejection fraction (HFrEF)
- Participants
- 173 patients
- Outcome
- Associations of 4210 repeatedly measured circulating proteins with echocardiographic parameters (LVEF, GLS, LASr) and elevated LAP (E/e' ratio >15)
- Follow-up
- Median 2.7 (IQR 2.5-2.8) years
Methodological detailsrepeated measurements, 6-monthly echocardiography, trimonthly blood sampling
- Repeated measurements
- 6-monthly echocardiography
- Trimonthly blood sampling
Main finding
As reported in the abstract
Proteins significantly associated with echocardiographic parameters
- Proteins associated with left ventricular ejection fraction (LVEF)
- 723
- Proteins associated with global longitudinal strain (GLS)
- 249
- Proteins associated with LASr
- 792
- Proteins associated with E/e' ratio
- 427
- Proteins associated with elevated left atrial pressure (LAP)
- 49
- Proteins remaining after correction for LVEF (cystatin-D, fibulin-5, HSP40)
- three
Observational data: associations, not effects.
Original publication
The plasma proteome is linked with left ventricular and left atrial function parameters in patients with chronic heart failure. Eur Heart J Cardiovasc Imaging. Published 10 April 2024. doi:10.
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