Heart failure & cardiomyopathies
Etiology and Phenotypes of Cardiomyopathy in Southern Africa: The IMHOTEP Multicenter Pilot Study
Authors' conclusion
In the largest study of cardiomyopathy to-date on the African continent, we observe that DCM is the dominant form of cardiomyopathy in Southern Africa. The age of onset was significantly younger in African patients with notable sex and ethnic disparities in DCM.
Study context
- Population
- Patients aged ≥13 years with cardiomyopathy or myocarditis, 3 centres in South Africa and 1 in Mozambique (IMHOTEP registry)
- Participants
- 665 unrelated index cases
- Exposure
- Dilated cardiomyopathy (DCM) vs arrhythmogenic cardiomyopathy (ACM) vs hypertrophic cardiomyopathy (HCM) vs restrictive cardiomyopathy (RCM)
- DCMn = 478
- ACMn = 78
- HCMn = 70
- RCMn = 39
- Outcome
- Cardiomyopathy phenotype distribution
Main finding
As reported in the abstract
DCM
72%
478
ACM
78
events
HCM
70
events
RCM
39
events
- Familial etiology
- 27%
- Nonfamilial/idiopathic etiology
- 36%
- Secondary etiology
- 37%
Observational data: associations, not effects.
Original publication
Etiology and Phenotypes of Cardiomyopathy in Southern Africa: The IMHOTEP Multicenter Pilot Study. JACC Adv. Published 8 May 2024. doi:10.
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