Heart failure & cardiomyopathies
Evaluation of Left Ventricular Systolic Function in Opium Users by Strain Echocardiography
Authors' conclusion
Evaluation of systolic left ventricular function in opium users by strain echocardiography showed that opium affects the systolic function of the heart, as observed by a significant reduction in EF and GLS.
Study context
- Population
- Opium users referred to addiction treatment centres and healthy controls, Shafa Hospital, Kerman, Iran, 2022
- Participants
- 100 users
- Comparison
- Opium users vs non-opium users
- Opium usersn = 50
- Controln = 50reference
- Outcome
- LV systolic function (EF, GLS) by strain echocardiography; association with serum apelin
Methodological detailsage- and sex-matched, single-centre
- Age- and sex-matched
- Single-centre
Main finding
As reported in the abstract
EF and GLS
- Mean ejection fraction (EF) and global longitudinal strain (GLS) significantly lower in opium users than controls
- P < 0.001
Observational data: associations, not effects.
Further findings
- Serum apelin level — Serum apelin lower in addicted vs non-addicted persons · addicted 3.4 vs non-addicted 9.7
- 3.4 vs. 9.7 · P < 0.001
Original publication
Evaluation of Left Ventricular Systolic Function in Opium Users by Strain Echocardiography. ESC Heart Fail. Published 29 August 2024. doi:10.
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