Heart failure & cardiomyopathies
Evolution and prognostic value of left ventricular deformation and myocardial work parameters in transthyretin amyloid cardiomyopathy
Authors' conclusion
Multi-chamber strain assessment may improve the surveillance of patients with ATTR-CM, and myocardial work parameters may improve clinical risk stratification in this population.
Study context
- Population
- Patients with wild-type ATTR-CM diagnosed by international consensus
- Participants
- 113 patients
- Exposure
- Baseline vs 18-month follow-up
- Outcome
- Change in LV deformation and myocardial work, baseline to 18 months
- Follow-up
- 18 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
18 months
- LV end-diastolic diameter, LASRES, LV longitudinal strain, global work index (GWI) and global constructive work significantly decreased
- LV wall thickness increased
- LVEF, RV free wall strain (FWS), global wasted work (GWW) and global work efficiency did not alter significantly
Observational data: associations, not effects.
Further findings
Prognostic value of baseline strain parameters (death and HF hospitalization) · median follow-up 935 days (IQR 691-1159 days)
- Deaths
- 34
- Hospitalized for HF
- 12
- GWI, GWW, FWS and LASRES prognostic on multivariate analysis; significantly associated with risk of death and HF hospitalization
Original publication
Evolution and prognostic value of left ventricular deformation and myocardial work parameters in transthyretin amyloid cardiomyopathy. Eur Heart J Cardiovasc Imaging. Published 21 November 2023. doi:10.
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