Heart failure & cardiomyopathies
Risk Factors for Pre-Heart Failure or Symptomatic Heart Failure Based on NT-proBNP
Authors' conclusion
The accumulation of these risk factors was associated with a graded higher risk of pre-heart failure or symptomatic heart failure.
Study context
- Population
- Japanese general population aged 30–69 years (Circulatory Risk in Communities Study) with NT-proBNP measured 2010–201585 HF cases
- Participants
- 2,768 participants
- Exposure
- Cardiovascular risk factors vs reference categories
- Outcome
- Pre-HF or symptomatic HF (NT-proBNP >400 pg/mL or HF diagnosis on HF medication)
Main finding
As reported in the abstract
Pre-HF or symptomatic HF (NT-proBNP >400 pg/mL or diagnosed HF on HF medication)
Multivariable odds ratio (95% CI)
BMI 27-29.9 kg/m²vs BMI 21-22.9 kg/m²
5.70(2.70–12.0)
BMI ≥30 kg/m²vs BMI 21-22.9 kg/m²
5.91(2.19–16.0)
SBP ≥160 mmHgvs SBP <130 mmHg
2.49(1.01–6.13)
DBP ≥100 mmHgvs DBP <80 mmHg
2.87(1.23–6.68)
Diabetesvs Non-diabetes
5.16(2.14–12.4)
Current smokers ≥20 cigarettes/dayvs Never smokers
2.24(0.92–5.49)
≥2 risk factorsvs No risk factorsrisk factors: obesity, hypertension, diabetes, current smoker
6.80(3.69–12.5)
- Cases of HF identified
- 85
Observational data: associations, not effects.
Original publication
Risk Factors for Pre-Heart Failure or Symptomatic Heart Failure Based on NT-proBNP. ESC Heart Fail. Published 24 September 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →