Fatal, ischemic and bleeding risk of patients meeting the selection criteria of the TWILIGHT trial: Insights from a large percutaneous coronary intervention (PCI) registry
Main finding · All-cause deathResult — go to the resultHazard ratio 3.63 95% CI 1.70–7.77Authors' conclusion
Among patients not meeting the TWILIGHT exclusion criteria from a large PCI registry, the high-risk inclusion criteria of the TWILIGHT trial were met by the majority of patients and were associated with an increased risk of mortality and MI and a moderately elevated risk of bleeding.
Study context
- Population
- Patients undergoing PCI at a tertiary center 2012–2019 not meeting any TWILIGHT exclusion criterion (OAC, STEMI, cardiogenic shock, dialysis, prior stroke, thrombocytopenia)11,018 (83%) high risk
- Participants
- 13,136 patients
- Exposure
- High-risk vs low-risk patients
- Outcome
- All-cause death
- Follow-up
- 1 year after PCI
Methodological detailssingle-centre (tertiary center)
- Single-centre (tertiary center)
Main finding
As reported in the abstract
1 year
Hazard ratio
3.63
95% CI 1.70–7.77
By group
High-riskvs Low-risk
HR 3.63 (95% CI 1.70–7.77)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | High-risk | Low-risk | HR (95% CI) | |
|---|---|---|---|---|
| MI · 1 year | 1.8% | 0.6% | 2.81 (1.56–5.04) | |
| 0.20.5125Hazard ratio (log scale) |
Safety
| Outcome | High-risk | Low-risk | HR (95% CI) | |
|---|---|---|---|---|
| Major bleeding · 1 year | 3.3% | 1.8% | 1.86 (1.32–2.62) | |
| 0.20.5125Hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Fatal, ischemic and bleeding risk of patients meeting the selection criteria of the TWILIGHT trial: Insights from a large PCI registry. Am Heart J. Published 23 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →