Coronary disease & ACSRandomised controlled trial
Statin loading before coronary artery bypass grafting: a randomized trial
- Randomised controlled trial
- investigator-initiated
- double-blind
- placebo-controlled
- 14 centres in Germany
- Conducted November 2012 to April 2019
Authors' conclusion
Additional statin loading before CABG failed to reduce the rate of MACCE occuring within 30 days of surgery.
Study context
- Population
- Adults on long-term statin treatment (≥30 days) scheduled for isolated coronary artery bypass grafting (CABG)2,406 in modified ITT analysis
- Participants
- 2,635 adults
- Comparison
- Statin loading vs placebo before CABG
- Statinn = 1,203
- Placebon = 1,203reference
- Primary endpoint
- Major adverse cardiac and cerebrovascular events (MACCE):
- All-cause mortality
- MI
- Cerebrovascular event
- Follow-up
- Within 30 days after surgery
Primary result
As reported in the abstract
Odds ratio
0.93
95% CI 0.74–1.18
P = 0.562
By group
Statin vs Placebo
OR 0.93 (95% CI 0.74–1.18); P = 0.562
Secondary outcomes
Cardiac death and myocardial infarction (MI)
- Statin vs placebo: 12.1% vs. 13.5%; comparable between treatment arms
- OR 0.88, 95% CI 0.69-1.12; P = 0.300
- modified ITT
Area under the troponin T-release curve (myocardial injury)
- Statin vs placebo: median 0.398 vs. 0.394 ng/ml; comparable between treatment arms
- P = 0.333
Death · 12 months
- Statin vs placebo: 3.1% vs. 2.9%; comparable between treatment arms
- P = 0.825
Original publication
Statin loading before coronary artery bypass grafting: a randomized trial. Eur Heart J. Published 22 April 2023. doi:10.1093/eurheartj/ehad238
Summarised from the published abstract; every number is checked against it