Heart failure & cardiomyopathies
FEV1 is a major prognostic factor in diverse heart failure populations: findings from the Global Heart Failure registry
Authors' conclusion
In a diverse, multi-national HF cohort, reductions in FEV1 were independently associated with higher HF burden and poor health outcomes. The effect of lower FEV1 was generalizable across the HF spectrum and comparable to other major established HF prognostic factors.
Study context
- Population
- Heart failure (HF) participants with spirometry in 28 high-, middle-, and low-income countriesHF participants included in the analysis
- Participants
- 3,359 participants
- Comparison
- The association between baseline FEV1 with all-cause mortality, cardiovascular (CV) deaths, and all-cause hospitalizations
Methodological details28 high-, middle-, and low-income countries
- 28 high-, middle-, and low-income countries
Primary result
As reported in the abstract
HF burden, cardiac structural and functional impairment, health-related quality of life by FEV1 z-score
- Participants with lower FEV1 z-scores, even within the normal range (z-score>−2), showed increasing burden of HF, cardiac structural and functional impairment, and lower health-related quality of life
Further findings
All-cause mortality, CV mortality and hospitalizations · median 3.8 (IQR 2.1, 5.0) years
| HR (95% CI) | ||
|---|---|---|
| FEV1 z-score ≤ −2All-cause mortality; independently associated | 2.20 (1.61–3.01) | |
| FEV1 z-score ≤ −2CV mortality | 2.45 (1.64–3.66) | |
| FEV1 z-score ≤ −2Hospitalizations | 1.40 (1.12–1.74) | |
| 0.20.5125Hazard ratio (log scale) |
- All-cause mortality, CV mortality and hospitalizations: The effect sizes were comparable to those of other major prognostic factors.
Consistency of association across subgroups
- The association was consistent across populations from diverse socio-economic development, HF aetiology, HF types, and airflow obstruction
Original publication
FEV1 is a major prognostic factor in diverse heart failure populations: findings from the Global Heart Failure registry. ESC Heart Fail. Published 13 May 2026. doi:10.
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