Heart failure & cardiomyopathies
The Risk of Death According to Left Ventricular Ejection Fraction and Right Ventricular Dilatation in 17 321 Adults with Heart Failure from 40 High-, Middle- and Low-Income Countries – A Global Congestive Heart Failure (G-CHF) Study
Authors' conclusion
Reduced LVEF was associated with worse prognosis in ischaemic and idiopathic dilated cardiomyopathy but not in HF of other causes. RV enlargement was associated with a more marked increase in the risk of death.
Study context
- Population
- Patients with heart failure (HF) from 40 countries of different income levels
- Participants
- 17,321 patients40 countries
- Exposure
- Left ventricular ejection fraction (LVEF) categories and right ventricular (RV) enlargement
- Outcome
- Death
- Follow-up
- Median 2.1 (2.0-4.6) years
Methodological detailsmultinational
- Multinational
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
LVEF 40-49%vs LVEF ≥50%
0.88(0.80–0.97)
P = 0.009LVEF 30-39%vs LVEF ≥50%
0.96(0.88–1.05)
P = 0.40LVEF <30%vs LVEF ≥50%
1.18(1.08–1.29)
P < 0.0001RV enlargement
1.35(1.26–1.44)
P < 0.0001Observational data: associations, not effects.
Further findings
Death and HF hospitalization during follow-up (whole cohort)
- Died
- 5738 (33%)
- Hospitalized for HF
- 3569 (21%)
LVEF–death relation by HF aetiology (subgroup)
- Continuous inverse association in ischaemic HF and idiopathic dilated cardiomyopathy; no association in hypertensive, valvular and other HF
- Interaction p = 0.0010
Original publication
The Risk of Death According to Left Ventricular Ejection Fraction and Right Ventricular Dilatation in 17 321 Adults with Heart Failure from 40 High-, Middle- and Low-Income Countries – A Global Congestive Heart Failure (G-CHF) Study. Eur J Heart Fail. Published 15 December 2024. doi:10.
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