Heart failure & cardiomyopathies
Fibrosis-4 Index Identifies Worsening Renal Function Associated with Adverse Outcomes in Acute Heart Failure
Main finding · 1-year all-cause mortalityResult — go to the resultHazard ratio 2.11 95% CI 1.07–4.18Authors' conclusion
FIB-4 is a valuable risk stratification marker for WRF in patients with acute HF.
Study context
- Population
- Patients aged ≥20 years hospitalized for acute heart failure (HF) with BNP ≥100 pg/mL at admission, single university hospital, January 2015–June 2021118 (12%) with worsening renal function (WRF)
- Participants
- 969 patients
- Exposure
- WRF and FIB-4 strata
- No WRF, lower FIB-4n = 428reference
- No WRF, higher FIB-4n = 423
- WRF, lower FIB-4n = 56
- WRF, higher FIB-4n = 62
- Outcome
- All-cause mortality
- Follow-up
- Within 1 year of discharge
Methodological detailssingle-centre registry
- Single-centre registry
Main finding
1-year all-cause mortality
Hazard ratio
2.11
95% CI 1.07–4.18
P = 0.032
By group
WRF, higher FIB-4vs No WRF, lower FIB-4
HR 2.11 (95% CI 1.07–4.18); P = 0.032
As reported in the abstract
- Difference across 4 groups
- P = 0.005
- Higher mortality in WRF and higher FIB-4 group (Kaplan-Meier)
- log-rank P = 0.003
Observational data: associations, not effects.
Original publication
Fibrosis-4 Index Identifies Worsening Renal Function Associated with Adverse Outcomes in Acute Heart Failure. ESC Heart Fail. Published 25 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →