Heart failure & cardiomyopathies
Assessing LV Contractility Identifies Populations With Preserved Ejection Fraction at Risk of Adverse Heart Failure Outcomes
Authors' conclusion
CCI is a simple, noninvasive, relatively afterload-independent method to stratify HF risk in populations with normal LVEF. Its simplicity means CCI could be applied to existing clinical trial data sets or used be as an inclusion criterion in future randomized controlled trials.
Study context
- Population
- People newly diagnosed with heart failure (HF); UK Biobank participants without HF and normal left ventricular ejection fraction (LVEF)
- Exposure
- Below-median cardiac contractility index (CCI) vs above median CCI
- Outcome
- Mortality over tertiles of declining CCI (people with HF)
Methodological detailsUK Biobank analysis
- UK Biobank analysis
Main finding
As reported in the abstract
- Mortality increased over tertiles of declining CCI
- P <0.001
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted hazard ratio (CI) | P value | |
|---|---|---|---|
| Incident HF (UK Biobank, without HF and normal LVEF)≈33% increased risk of incident HF | 1.33 (1.01–1.75) | P = 0.043 | |
| 0.512Adjusted hazard ratio (log scale) |
| Outcome | Below-median CCI | Above median CCI | P value |
|---|---|---|---|
| All-cause mortality, HF with preserved ejection fraction group | observed event rate 17.3/100 patient-years | observed event rate 8.8/100 patient-years | P < 0.001 |
- All-cause mortality, HF with preserved ejection fraction group: risk approximately twice that of those with above median CCI; similar to those with HF with reduced ejection fraction
Mortality modeled with CCI and LVEF as continuous variables
- No clear association with mortality risk across a wide range of LVEF
- 20%-55%
- Curvilinear relationship between mortality across the detected range of CCI
Myocardial contractility (global radial and circumferential strain)
- Decreasing CCI was also associated with lower myocardial contractility
Original publication
Assessing LV Contractility Identifies Populations With Preserved Ejection Fraction at Risk of Adverse Heart Failure Outcomes. Circ Cardiovasc Imaging. Published 16 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →