Heart failure & cardiomyopathies
Fractional Excretion of Urea Nitrogen Can Identify True Worsening Renal Function in Patients with Heart Failure
Authors' conclusion
The prognostic impact of WRF was significantly mediated by the FEUN values and was associated with worse outcomes only when the FEUN values were either low or high.
Study context
- Population
- Patients with acute heart failure (HF) (median age 78 years; 60% male); Worsening renal function (WRF) = serum creatinine increase ≥0.3 mg/dL from admission to discharge170 HF readmissions
- Participants
- 1,103 patients
- Exposure
- WRF by discharge fractional excretion of urea nitrogen (FEUN) category vs no WRF
- Outcome
- HF readmission after hospital discharge
- Follow-up
- 1 year
Main finding
As reported in the abstract
HF readmission · 1 year
- Among patients with WRF, readmission lowest with medium FEUN, then low FEUN, then high FEUN
- WRF with low or high FEUN independently associated with increased HF readmission vs no WRF with medium FEUN (multivariable analysis)
- No association between WRF with medium FEUN and HF readmission
- WRF vs No WRF: P < 0.001
Observational data: associations, not effects.
Original publication
Fractional Excretion of Urea Nitrogen Can Identify True Worsening Renal Function in Patients with Heart Failure. ESC Heart Fail. Published 24 March 2024. doi:10.
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