Arrhythmias & electrophysiology
Five-year outcomes following catheter ablation for paroxysmal atrial fibrillation: a propensity matched analysis of 51 182 patients from a real world cohort
Authors' conclusion
This large-scale study demonstrates that in PAF patients CA is associated with lower ischaemic stroke rates and all-cause mortality compared with a PSM group without CA. These findings support urgent evaluation of CA in managing PAF and highlight its role in potentially improving survival and reducing stroke risk. Further trials are needed to support these findings.
Study context
- Population
- Adults diagnosed with paroxysmal atrial fibrillation (PAF) between 2012 and 2019, TriNetX Research Networkpatients with PAF, 53,178 (6.7%) underwent catheter ablation (CA)
- Participants
- 791,013 adults
- Exposure
- CA vs non-CA groups
- CAn = 53,178
- Outcome
- Ischaemic stroke rates
- Follow-up
- Five years
Methodological detailspropensity score matching
- Propensity score matching
Main finding
As reported in the abstract
CA vs non-CAHazard ratio (95% CI)P value
Post-PSM
0.823(0.785–0.863)
P < 0.0001Excluding patients with prior ischaemic stroke (de novo ischaemic stroke): 4.70% vs. 6.43%
0.709(0.665–0.756)
P < 0.0001Observational data: associations, not effects.
Secondary outcomes
| Outcome | CA | non-CA | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| All-cause mortalitySecondary outcome | 9.33% | 20.68% | 0.388 (0.373–0.404) | P < 0.0001 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Five-year outcomes following catheter ablation for paroxysmal atrial fibrillation: a propensity matched analysis of 51 182 patients from a real world cohort. Eur Heart J Qual Care Clin Outcomes. Published 16 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →