Five-year outcomes of a drug-coated polymer-free biolimus-eluting stent versus an ultrathin-strut biodegradable-polymer sirolimus-eluting stent
Authors' conclusion
Five-year TLF did not differ significantly between the drug-coated biolimus-eluting stent group and the ultrathin-strut biodegradable-polymer stent group, but the risk of TLR was higher in the drug-coated biolimus-eluting stent group.
Study context
- Population
- All-comer patients treated with percutaneous coronary interventionpatients randomly assigned, 0.3% lost to follow-up, all due to emigration
- Participants
- 3,151 patients
- Comparison
- Drug-coated polymer-free biolimus-eluting stent versus an ultrathin-strut biodegradable-polymer sirolimus-eluting stent
- Polymer-free biolimus-coated stentn = 1,572 patients [1,966 lesions]
- Ultrathin-strut biodegradable-polymer sirolimus-eluting stentn = 1,579 patients [1,985 lesions]reference
- Primary endpoint
- TLF:
- Cardiac death
- MI not related to any segment other than the target lesion
- Target lesion revascularisation (TLR)
- Follow-up
- Within 1 year
Primary result
As reported in the abstract
- The biolimus A9-coated polymer-free stent was not non-inferior for target lesion failure (TLF) when compared with an ultrathin-strut biodegradable-polymer sirolimus-eluting stent within 1 year
Further findings
| Outcome | Polymer-free biolimus-coated stent | Ultrathin-strut biodegradable-polymer sirolimus-eluting stent | RR (95% CI) | |
|---|---|---|---|---|
| TLF · 5 yearsRate ratio | 14.1% | 12.0% | 1.19 (0.97–1.44) | |
| Clinically driven TLR · 5 yearsHigher in the polymer-free biolimus-coated stent group · attributable to a higher risk of TLR within the first year | 7.6% | 5.0% | 1.56 (1.17–2.07) | |
| 0.512Relative risk (log scale) |
Cardiac death, myocardial infarction (MI) and definite stent thrombosis · 5 years
- Did not differ between the two groups
Follow-up completeness · 5 years
- Lost to follow-up, all due to emigration
- 0.3%
Original publication
Five-year outcomes of a drug-coated polymer-free biolimus-eluting stent versus an ultrathin-strut biodegradable-polymer sirolimus-eluting stent. EuroIntervention. Published 2 June 2025. doi:10.
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