Arrhythmias & electrophysiology
Follicle-stimulating hormone promotes atrial fibrosis in menopausal women with atrial fibrillation
Authors' conclusion
Postmenopausal women exhibited a higher LVA burden than men, which was positively correlated with FSH level. FSH promoted atrial fibrosis through oxidative stress.
Study context
- Population
- Women with atrial fibrillation (AF) (prospective cohort); CREM-IbΔC-X mice (spontaneous AF model) and Ang II-induced pressure overload mice
- Outcome
- LVA burden (women vs men) and its correlation with FSH level; AF incidence and atrial fibrosis in mice (OVX vs Sham; FSH stimulation in males)
Methodological detailsprospective cohort, mouse models
- Prospective cohort
- Mouse models
Main finding
As reported in the abstract
- Women: significantly higher low-voltage area (LVA) burden than men
- P < .001
- Positive correlation between LVA burden and follicle-stimulating hormone (FSH) level
- P = .002
- OVX vs Sham mice: higher incidence of AF
- P = .040
- OVX vs Sham mice: higher atrial fibrosis
- P = .021
- Male CREM-IbΔC-X mice, FSH stimulation: promoted AF occurrence
- P = .035
- Male CREM-IbΔC-X mice, FSH stimulation: promoted atrial fibrosis
- P = .002
Original publication
Follicle-stimulating hormone promotes atrial fibrosis in menopausal women with atrial fibrillation. Heart Rhythm. Published 14 September 2024. doi:10.
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