Fractional Flow Reserve–Negative High-Risk Plaques and Clinical Outcomes After Myocardial Infarction
Main findingResult — go to the resultHazard ratio 1.93 95% CI 1.08–3.47Authors' conclusion
Among patients with MI and FFR-negative nonculprit lesions, the presence of a high-risk plaque is associated with a worse clinical outcome, which is mainly driven by a higher number of unplanned revascularizations.
Study context
- Population
- Patients with myocardial infarction (MI) (STEMI or NSTEMI) with fractional flow reserve (FFR)-negative (FFR > 0.80) nonculprit lesions imaged by optical coherence tomography (OCT)420 with analysable OCT
- Participants
- 438 patients
- Exposure
- High-risk plaque vs No high-risk plaque
- High-risk plaquen = 143
- No high-risk plaquen = 277reference
- Outcome
- Major adverse cardiovascular events (MACE):
- All-cause mortality
- Nonfatal MI
- Unplanned revascularization
- Follow-up
- 2-year follow-up
Methodological detailsinternational, multicentre, observational
- International
- Multicentre
- Observational
Main finding
As reported in the abstract
Hazard ratio
1.93
95% CI 1.08–3.47
P = 0.02
Events by group
High-risk plaque vs No high-risk plaque
HR 1.93 (95% CI 1.08–3.47); P = 0.02
Observational data: associations, not effects.
Further findings
Unplanned revascularization
P = 0.02
Original publication
Fractional Flow Reserve–Negative High-Risk Plaques and Clinical Outcomes After Myocardial Infarction. JAMA Cardiol. Published 1 November 2023. doi:10.
Summarised from the published abstract; every number is checked against it