Acute cardiac care & resuscitation
Long-term outcomes after acute kidney injury in myocardial infarction complicated by cardiogenic shock: a retrospective, observational study
Authors' conclusion
AKI was associated with increased short- and long-term mortality and morbidity, including CKD and dialysis, but not new cardiovascular events.
Study context
- Population
- Patients admitted with acute myocardial infarction cardiogenic shock in Denmark between 2010 and 2017 with data on kidney function from the RETROSHOCK cohort
- Participants
- 1,473 patients
- Exposure
- Patients with acute kidney injury (AKI) vs patients without AKI
- Outcome
- Frequency of AKI and RRT
Main finding
As reported in the abstract
Developed AKI
44%
Required renal replacement therapy (RRT)
25%
Observational data: associations, not effects.
Further findings
Risk factors for AKI development
- AKI development associated with increasing age, diabetes, low ejection fraction and high lactate levels on admission
- P < 0.05
Mortality · 30 days, 1, 5 and 10 years
- At 10 years follow-up mortality increased by more than 30%
- P < 0.001
- Mortality significantly increased in patients with AKI at 30 days and at 1-, 5- and 10-years follow-up
10-year cumulative incidence of chronic kidney disease (CKD) and dialysis, accounting for competing risk of death
- Significantly higher in patients treated with RRT during admission
- P < 0.001
- Competing risks regression
Original publication
Long-term outcomes after acute kidney injury in myocardial infarction complicated by cardiogenic shock: a retrospective, observational study. Eur Heart J Acute Cardiovasc Care. Published 1 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it