Heart failure & cardiomyopathies
Frailty and outcomes in heart failure patients from high-, middle-, and low-income countries
Authors' conclusion
Frailty confers substantial incremental prognostic information to prognostic variables for predicting death and HF hospitalization. The relationship between frailty and these outcomes is consistent across countries at all income levels.
Study context
- Population
- Adults with heart failure (HF) from 27 high-, middle- and low-income countries (age 61 ± 14 years, 33% women; mean LVEF 39 ± 14%; 26% NYHA III/IV)
- Participants
- 3,429 adults
- Exposure
- Pre-frail and frail vs robust
- Outcome
- Death and HF hospitalization
- Follow-up
- Median 3.1 (2.0-4.3) years
Methodological details27 high-, middle- and low-income countries
- 27 high-, middle- and low-income countries
Main finding
As reported in the abstract
Death
Each group vs robustAdjusted hazard ratio (95% CI)
Pre-frail
1.59(1.12–2.26)
Frail
2.92(1.99–4.27)
- Adjusted HR (95% CI) for HF hospitalization, pre-frail and frail respectively
- 1.32 (0.93-1.87) and 1.97 (1.33-2.91)
- Overall during follow-up: died
- 565 (16%)
- Overall during follow-up: hospitalized for HF
- 471 (14%)
Observational data: associations, not effects.
Further findings
Consistency by country income level and subgroups
- Findings consistent among different country income levels and by most subgroups
Discrimination beyond MAGGIC risk score (AUC)
- Adding frailty to MAGGIC risk score improved discrimination of future death and HF hospitalization
Original publication
Frailty and outcomes in heart failure patients from high-, middle-, and low-income countries. Eur Heart J. Published 28 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →