Prevention & lipidsCohort study
From plasma triglycerides to triglyceride metabolism: effects on mortality in the Copenhagen General Population Study
- Prospective cohort study
- nested within the Copenhagen General Population Study
Authors' conclusion
This study observed an increased risk of all-cause, cardiovascular, cancer, and other mortality with higher triglyceride metabolism. This was not explained by higher plasma triglycerides and body mass index.
Study context
- Population
- Individuals from the Copenhagen General Population Studynested within 109,751
- Participants
- 30,000 individuals
- Exposure
- Highest vs lowest fourth of plasma glycerol and β-hydroxybutyrate
- Outcome
- All-cause mortality
- Follow-up
- Median 10.7 years
Main finding
As reported in the abstract
HR
Glycerol >80 µmol/L vs Glycerol <52 µmol/L
1.31(95% CI 1.22–1.40)
β-hydroxybutyrate >154 µmol/L vs β-hydroxybutyrate <91 µmol/L
1.18(CI 1.11–1.26)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| CV mortality — Glycerol >80 µmol/L vs Glycerol <52 µmol/L | 1.37 (1.18–1.59) | |
| CV mortality — β-hydroxybutyrate >154 µmol/L vs β-hydroxybutyrate <91 µmol/L | 1.18 (1.03–1.35) | |
| Cancer mortality — Glycerol >80 µmol/L vs Glycerol <52 µmol/L | 1.24 (1.11–1.39) | |
| Cancer mortality — β-hydroxybutyrate >154 µmol/L vs β-hydroxybutyrate <91 µmol/L | 1.16 (1.05–1.29) | |
| Other mortality — Glycerol >80 µmol/L vs Glycerol <52 µmol/L | 1.45 (1.28–1.66) | |
| Other mortality — β-hydroxybutyrate >154 µmol/L vs β-hydroxybutyrate <91 µmol/L | 1.23 (1.09–1.39) | |
| 0.512Hazard ratio (log scale) |
- CV mortality: 2204 CV deaths
- Cancer mortality: 3366 cancer deaths
- Other mortality: 2745 deaths from other causes
Sensitivity analyses
- Results robust to excluding first years of follow-up, to stratification for covariates incl. plasma TG and BMI, and to further adjustments
Original publication
From plasma triglycerides to triglyceride metabolism: effects on mortality in the Copenhagen General Population Study. Eur Heart J. Published 14 August 2023. doi:10.1093/eurheartj/ehad330
Summarised from the published abstract; every number is checked against it