Functional coronary angiogram findings in angina with non-obstructive coronary arteries patients with coronary slow flow
Authors' conclusion
The conventional marker of CMD (i.e. CFR <2) was similar in patients with/without the CSFP. However alternative hemodynamic markers of impaired coronary microvascular function were abnormal in patients with the CSFP, including resting/hyperemic coronary microvascular resistance. Moreover, cTFC is a simple semi-quantitative marker correlated with coronary microvascular resistance and thus has clinical utility in the diagnosis of the CSFP.
Study context
- Population
- Patients with angina and non-obstructive coronary artery disease (<50% stenosis; ANOCA) undergoing functional coronary angiography
- Participants
- 103 patients
- Exposure
- Coronary Slow Flow Phenomenon (CSFP) vs no CSFP
- CSFPn = 69
- No CSFPn = 34reference
- Outcome
- Functional coronary angiography findings
Main finding
As reported in the abstract
| Group | Coronary microvascular dysfunction (CMD) (Coronary Flow Reserve (CFR)<2) | Inducible coronary artery spasm | Microvascular spasm |
|---|---|---|---|
| CSFP | 43% | 58% | 13% |
CSFP
Coronary microvascular dysfunction (CMD) (Coronary Flow Reserve (CFR)<2)43%
Inducible coronary artery spasm58%
Microvascular spasm13%
- CSFP vs No CSFP: P = 0.009 — 19 ± 7 vs 23 ± 7
- CSFP vs No CSFP: P = 0.006 — 5.8 ± 1.9 vs 4.4 ± 1.7
- CSFP vs No CSFP: P = 0.049 — 2.35 ± 1.09 vs 1.94 ± 0.93
- CSFP vs No CSFP: P = 0.971 — 2.25 ± 0.84 vs 2.26 ± 0.58
Observational data: associations, not effects.
Further findings
cTFC (continuous) correlations
- cTFC correlated with resting coronary blood flow and resting/hyperemic resistance but not CFR
Original publication
Functional coronary angiogram findings in angina with non-obstructive coronary arteries patients with coronary slow flow. Am Heart J. Published 9 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →