Utility of 18 F-Flurpiridaz PET Relative Flow Reserve in Differentiating Obstructive From Nonobstructive Coronary Artery Disease
Primary result · RFR per vesselResult — go to the resultOdds ratio 3.08 95% CI 1.49–6.38Authors' conclusion
RFR provides complementary diagnostic information beyond existing positron emission tomography parameters and may help refine the diagnosis of obstructive CAD in patients with reduced flows.
Study context
- Population
- Patients in the phase III 18F-flurpiridaz PET trial with available myocardial blood flow (MBF) quantification (71% male; 56% with established coronary artery disease (CAD))from 755 trial participants
- Participants
- 231 patients
- Comparison
- PET relative flow reserve (RFR) added to existing PET parameters for diagnosis of obstructive CAD
- Primary endpoint
- Incremental diagnostic value of PET-derived RFR for obstructive CAD (≥70% stenosis on quantitative invasive coronary angiography)
Methodological detailspost hoc diagnostic accuracy study, multicentre, No patients had 3-vessel CAD
- Post hoc diagnostic accuracy study
- Multicentre
- No patients had 3-vessel CAD
Primary result
RFR per vessel
Odds ratio
3.08
95% CI 1.49–6.38
P = 0.002
By group
Obstructive CAD
0.55
Nonobstructive CAD
0.80
RFR
OR 3.08 (95% CI 1.49–6.38); P = 0.002
Per vessel, as printed
As reported in the abstract
Further findings
Discrimination of obstructive CAD with addition of RFR (AUC)
- Addition of RFR did not significantly improve discrimination (AUC 0.806 vs 0.822)
- P = 0.11
Reclassification of vessels with addition of RFR
- Net reclassification index
- 0.93
- Obstructive CAD net reclassification index
- 0.44
- Nonobstructive CAD net reclassification index
- 0.49
- P<0.0001
Vessels with reduced stress MBF (sMBF) without obstructive CAD on invasive coronary angiography (per-vessel)
- Vessels with reduced sMBF with no obstructive CAD
- 82%
Original publication
Utility of 18 F-Flurpiridaz PET Relative Flow Reserve in Differentiating Obstructive From Nonobstructive Coronary Artery Disease. Circ Cardiovasc Imaging. Published 9 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →