Valvular & structural heart disease
A Geriatric Assessment Score Predicting 1-Year Mortality and Functional Decline After Transcatheter Aortic Valve Replacement (TAVR): The GASS-TAVR Study
Authors' conclusion
A geriatric assessment-based model significantly improved the prediction of 1-year mortality or functional decline in older TAVR candidates
Study context
- Population
- Patients ≥75 years with severe symptomatic AS evaluated for TAVR, Italy, 2020–2022
- Participants
- 562 patients
- Exposure
- Derivation vs Validation
- Outcome
- All-cause mortality or significant functional decline (loss of ≥2 BADL or failure to improve if already impaired)
- Follow-up
- 1 year
Methodological detailsprediction model development and validation, 3 high-volume academic centres in Italy, consecutive patients, 66% derivation / 34% validation cohort
- Prediction model development and validation
- 3 high-volume academic centres in Italy
- Consecutive patients
- 66% derivation / 34% validation cohort
Main finding
As reported in the abstract
Prediction of 1-year all-cause mortality or significant functional decline (composite)
Derived score discrimination, AUC
0.92
95% CI 0.88–0.96
Validation performance, AUC (95% CI 0.79-0.95); outperformed STS score
0.87
Composite outcome met
78
13.9%
Observational data: associations, not effects.
Further findings
Primary outcome incidence (whole cohort) · 11 months (Q1-Q3: 10-12 months)
- Met the primary outcome
- 78 (13.9%)
Independent predictors of the composite outcome
- Mini Nutritional Assessment-Short Form score, basic activities of daily living (BADL), lower eGFR and elevated pulmonary artery systolic pressure independently associated
Original publication
A Geriatric Assessment Score Predicting 1-Year Mortality and Functional Decline After TAVR: The GASS-TAVR Study. JACC Cardiovasc Interv. Published 13 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →