Heart failure & cardiomyopathies
Gene Expression Omnibus (GEO) Combined with Quantitative Protein Trait Loci Identify Causative Proteins in Hypertrophic Cardiomyopathy
Main finding · HCM risk, CA3Result — go to the resultOdds ratio 1.292 95% CI 1.021–1.636Authors' conclusion
CA3 and SERPINE1 proteins may exert causal effects on HCM and may serve as characteristic markers and therapeutic targets for this condition.
Study context
- Population
- Hypertrophic cardiomyopathy (HCM) cardiac tissue samples and healthy controls from GEO; Protein quantitative trait locus (pQTL) data from UK Biobank plasma; HCM genome-wide association study (GWAS) data from the FinnGen studyGSE36961 HCM samples 106 · GSE36961 healthy controls 39 · GSE180313 HCM samples 13 · GSE180313 healthy controls 7 · UK Biobank participants (pQTL) 54,000 · FinnGen HCM cases 1,125 · FinnGen controls 411,056
- Comparison
- Causal association between these protein phenotypes and HCM
- Outcome
- HCM risk, CA3
Methodological detailssensitivity analysis of heterogeneity and horizontal pleiotropy tests
- Sensitivity analysis of heterogeneity and horizontal pleiotropy tests
Main finding
As reported in the abstract
Odds ratio
1.292
95% CI 1.021–1.636
P = 0.033
CA3
OR 1.292 (95% CI 1.021–1.636); P = 0.033
Further findings
HCM risk, SERPINE1
| OR (95% CI) | P value | ||
|---|---|---|---|
| SERPINE1IVW | 1.313 (1.063–1.621) | P = 0.011 | |
| 0.512Odds ratio (log scale) |
Heterogeneity and horizontal pleiotropy
- No significant heterogeneity
- P > 0.05
- No evidence of horizontal pleiotropy
- P > 0.05
Original publication
GEO Combined with Quantitative Protein Trait Loci Identify Causative Proteins in Hypertrophic Cardiomyopathy. ESC Heart Fail. Published 9 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →