Heart failure & cardiomyopathiesCohort study
Plasma protein profiles in different heart failure phenotypes
- UK Biobank cohort analysis with multivariable adjusted Cox models
- correction for multiple testing
Authors' conclusion
A plasma protein profile associated with heart failure independently of prior MI or AF was identified. This protein profile represents several pathophysiological pathways of interest, and some of these proteins were also related to either LV-EF or the E/A ratio. In addition, a number of proteins were found to be uniquely associated with only one of the three HF traits.
Study context
- Population
- UK Biobank participants with measurements on 2922 plasma proteins; participants who developed heart failure (HF) after enrolmentUK Biobank participants with measurements on 2922 plasma proteins · UK Biobank (UKB) participants with magnetic resonance-measured left ventricular ejection fraction (LV-EF) 5,097 · POEM study participants with echocardiography-measured E/A-ratio 502
- Participants
- 50,765 participants
- Exposure
- associations between protein measurements and incident HF
- MI-HFn = 269
- AF-HFn = 519
- noMInoAF-HFn = 1,059
Main finding
As reported in the abstract
noMInoAF-HF
110
events
AF-HF
21
events
MI-HF
one protein (ADGRG2)
events
Observational data: associations, not effects.
Further findings
HR
| Outcome | MI-HF | AF-HF | noMInoAF-HF |
|---|---|---|---|
| LRRN1 and incident HF (inverse association) | 0.49 (95% CI 0.36–0.67) | 0.51 (95% CI 0.41–0.63) | 0.58 (95% CI 0.50–0.68) |
| ADM and incident HF (top association) | 5.19 (95% CI 3.06–8.78) | 7.78 (95% CI 5.31–11.41) | Not reported in the abstract |
Proteins associated with HF across all three HF groups
- Same proteins significantly associated with HF across all three HF groups
- 60
- Of these, related to LV-EF
- 13
- Of these, another associated with the E/A-ratio
- 7
LRRN1 and incident HF (inverse association)
- All remaining proteins were positively associated with HF
Enriched pathways for the 60 shared proteins
- interleukin-10 signalling, transcription of death receptors, and TNF receptor binding
Original publication
Summarised from the published abstract; every number is checked against it