Heart failure & cardiomyopathies
Global constructive work is associated with ventricular arrhythmias after cardiac resynchronization therapy
Authors' conclusion
In patients treated with CRT-D, a GCW below median level was associated with a five-fold increase in the risk of ventricular arrhythmias.
Study context
- Population
- Patients on guideline-recommended treatment with a cardiac resynchronization therapy (CRT) defibrillator (CRT defibrillator (CRT-D)), assessed by 2D speckle-tracking echocardiography ≥6 months after implantation
- Participants
- 162 patients
- Exposure
- Below-median vs above-median global constructive work
- Outcome
- Composite of:
- Appropriate defibrillator therapy
- Sustained ventricular arrhythmia under the monitor zone
- Follow-up
- Median 18 months (IQR: 12-25)
Main finding
As reported in the abstract
Below-median GCW vs Above-median GCWHazard ratio (95% CI)P value
Univariate model
8.14(1.83–36.08)
P = 0.006Adjusted for eGFR and QRS duration
4.75(1.01–22.28)
P < 0.05- Patients with primary outcome (overall)
- 16 (10%)
Observational data: associations, not effects.
Original publication
Global constructive work is associated with ventricular arrhythmias after cardiac resynchronization therapy. Eur Heart J Cardiovasc Imaging. Published 25 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →