Heart failure & cardiomyopathies
Association of interventricular activation delay with clinical outcomes in cardiac resynchronization therapy
Authors' conclusion
Among CRT patients with quadripolar LV pacing leads, longer baseline interventricular activation delay was significantly associated with the composite endpoint of all-cause mortality and HFH.
Study context
- Population
- Cardiac resynchronization therapy (CRT) patients implanted with Acuity X4 quadripolar left ventricular (LV) leads (RALLY-X4)complete RV-LV delay data
- Participants
- 581 patients
- Exposure
- Long vs short RV-LV delay
- Outcome
- Composite of:
- All-cause mortality
- HF hospitalization
- Follow-up
- 18 months
Main finding
As reported in the abstract
Survival free of primary outcome
P = 0.0042
Observational data: associations, not effects.
Further findings
Survival free of HF hospitalization (multivariate analysis)
- RV-LV delay an independent predictor of survival free of heart failure hospitalization (HFH)
- P = 0.028
Predictors of long RV-LV delay
- Female sex, LBBB and QRS duration >150 ms predicted long RV-LV delay
Original publication
Association of interventricular activation delay with clinical outcomes in cardiac resynchronization therapy. Heart Rhythm. Published 24 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →