Heart failure & cardiomyopathies
Circulating Growth Differentiation Factor-15 Levels are Associated with Early Echocardiographic Signs of Diastolic Function Impairment in the STANISLAS Cohort: A 20-Year Follow-Up Study
Authors' conclusion
In the STANISLAS cohort, initial circulating GDF-15 levels were associated with echocardiographic signs of reduced LV size and increased filling pressure almost two decades later.
Study context
- Population
- Initially healthy populational familial cohort (STANISLAS cohort)1,562 with GDF-15 at V1
- Participants
- 1,679 participants
- Exposure
- Higher vs lower circulating GDF-15 levels
- Outcome
- Adverse changes in echocardiographic indexes of cardiac structure and function
Methodological detailspopulation-based familial cohort, long follow-up
- Population-based familial cohort
- Long follow-up
Main finding
As reported in the abstract
18.2 ± 1.4 years
- Higher baseline GDF-15 associated with lower left ventricular (LV) end-diastolic volume and higher E/e' ratio nearly two decades later (adjusted)
- p ≤ 0.01
Observational data: associations, not effects.
Further findings
Cross-sectional GDF-15 at V4 and echocardiographic variables
- Significant associations with LV end-diastolic volume, higher E/e' ratio and impaired LV strain
Original publication
Circulating Growth Differentiation Factor-15 Levels are Associated with Early Echocardiographic Signs of Diastolic Function Impairment in the STANISLAS Cohort: A 20-Year Follow-Up Study. Eur J Heart Fail. Published 21 January 2025. doi:10.
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