Arrhythmias & electrophysiology
GSTP1 inhibits angiotensin II-induced atrial fibrillation by regulating ferroptosis
Authors' conclusion
Therefore, these results preliminarily demonstrate that GSTP1-mediated ferroptosis plays a crucial role in the Ang II-induced atrial fibrillation model
Study context
- Population
- Ang II-induced AF mouse model; NRAMs; human atrial tissues
Methodological detailsmouse model, in vitro, human atrial tissue
- Mouse model
- In vitro
- Human atrial tissue
Main finding
As reported in the abstract
- Ferroptosis pathway significantly altered in AF (proteomics)
- Ferroptosis inhibitor Fer-1 intervened in Ang II-induced AF
- GSTP1 expression significantly decreased in AF; verified in cells and human atrial tissues
- GSTP1 overexpression (AAV9-cTNT-GSTP1) inhibited Ang II-induced AF in mice
- GSTP1 overexpression inhibited Ang II-induced myocardial injury, oxidative stress and ferroptosis in vitro
Original publication
GSTP1 inhibits angiotensin II-induced atrial fibrillation by regulating ferroptosis. Europace. Published 5 April 2025. doi:10.
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