Arrhythmias & electrophysiology
Electrocardiographic P-wave parameters and lifetime atrial fibrillation risk: A multicohort study
Authors' conclusion
Multiple P-wave parameters are associated with increased lifetime risk of AF, with a strong dose-response relationship for cumulative abnormalities. These findings suggest that comprehensive ECG analysis may enhance long-term AF risk assessment.
Study context
- Population
- Participants of 4 prospective cohort studies with baseline electrocardiogram (ECG) P-wave parameterspooled from 4 prospective cohort studies
- Participants
- 25,508 participants
- Comparison
- Lifetime risk of atrial fibrillation (AF) stratified by individual and cumulative ECG P-wave abnormalities
- Outcome
- Incident AF
- Follow-up
- During
Methodological detailsmulticohort
- Multicohort
Pooled result
As reported in the abstract
AF developed
2877 participants
11.3%
Further pooled results
| Outcome | Values |
|---|---|
| Lifetime AF risk by number of cumulative ECG abnormalitiesDose-response relationship | 0-1 abnormalities lifetime risk 22.9% · 2 abnormalities lifetime risk 27.0% · 3 abnormalities lifetime risk 30.7% · 4+ abnormalities lifetime risk 35.7% |
| Average years lived free of AF | 4+ ECG abnormalities average 17.1 years · none average 21.7 years |
Lifetime AF risk by individual P-wave abnormality · index age 45 years
- Interatrial block (strongest association): with vs without
- 35.4% vs 23.9%
- Lead II area: with vs without
- 30.0% vs 24.6%
- P-wave dispersion >70 ms: with vs without
- 28.8% vs 23.6%
Original publication
Electrocardiographic P-wave parameters and lifetime atrial fibrillation risk: A multicohort study. Heart Rhythm. Published 4 April 2025. doi:10.
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