Heart failure & cardiomyopathies
Guideline-Directed Medical Therapy Assessment in Heart Failure Patients Undergoing Percutaneous Mitral Valve Repair
Main finding · All-cause mortality per 1-point increase in GDMT scoreResult — go to the resultHazard ratio 0.90 95% CI 0.86–0.95Authors' conclusion
This study demonstrates the utility of a simple GDMT scoring system for assessing the adequacy of GDMT in HFrEF patients with relevant SMR undergoing M-TEER.
Study context
- Population
- Heart failure with reduced ejection fraction (HFrEF) (LVEF ≤ 40%) patients with secondary mitral regurgitation (SMR) undergoing M-TEER, EuroSMR Registryof 1641 EuroSMR patients
- Participants
- 1,072 participants
- Exposure
- Guideline-directed medical therapy (GDMT) score
- Outcome
- All-cause mortality
Main finding
As reported in the abstract
All-cause mortality per 1-point increase in GDMT score
Hazard ratio
0.90
95% CI 0.86–0.95
GDMT score (per 1-point increase)
HR 0.90 (95% CI 0.86–0.95)
Per 1-point increase, as printed
- All three GDMT score domains associated with all-cause mortality
- P < 0.05 for all
Observational data: associations, not effects.
Further findings
GDMT score distribution (max 12 points)
- Median GDMT score, points (IQR 3-6)
- 4
Original publication
Guideline-Directed Medical Therapy Assessment in Heart Failure Patients Undergoing Percutaneous Mitral Valve Repair. ESC Heart Fail. Published 13 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →