Heart failure & cardiomyopathies
Factors associated with high-intensity physical activity and sudden cardiac death in hypertrophic cardiomyopathy
Authors' conclusion
High-intensity physical activity-related sudden cardiac death in hypertrophic cardiomyopathy is associated with younger age; however, in this small cohort, no associations were found with traditional risk factors, including left ventricular hypertrophy or obstructive physiology.
Study context
- Population
- Patients with hypertrophic cardiomyopathy with documented sudden cardiac death events, evaluated between 2005 and 2023patients with documented sudden cardiac death events from a cohort of 2619 patients with hypertrophic cardiomyopathy
- Participants
- 75 patients
- Exposure
- Clinical and imaging characteristics, cardiopulmonary exercise test findings and genetic data compared between high-intensity and low-intensity to moderate-intensity activity-related sudden cardiac death events
- High-intensityn = 15
- Outcome
- Sudden cardiac death events during high-intensity activity
Main finding
As reported in the abstract
Among the 75 patients, experienced sudden cardiac death events during high-intensity activity
15
20%
Observational data: associations, not effects.
Further findings
Age · younger with high-intensity
P < 0.001
Median
| Outcome | High-intensity | Low-intensity to moderate-intensity | P value |
|---|---|---|---|
| European Society of Cardiology sudden cardiac death risk scoreHigher with high-intensity | 4.9 | 2.4 | P = 0.023 |
Ventricular arrhythmias during exercise testing
- Fewer ventricular arrhythmias during exercise testing with high-intensity activity-related events
Left ventricular hypertrophy, LV outflow tract obstruction, LV systolic or diastolic function, genetic findings
- No differences between groups
Independent risk factors of high-intensity activity-related sudden cardiac death events
- Younger age was the only independent risk factor
- Multivariable analysis
Recurrent events in survivors of initial high-intensity activity-related sudden cardiac death
- Recurrent events were triggered by subsequent high-intensity activity
Original publication
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