Arrhythmias & electrophysiology
Healthcare Expenditure on Atrial Fibrillation in the United States: The Medical Expenditure Panel Survey 2016 to 2021
Authors' conclusion
AF is associated with substantial and increasing healthcare expenditures. With changing screening and management, expenditures need periodic reassessments.
Study context
- Population
- Adults in the United States with atrial fibrillation (AF) or atrial flutter identified using International Classification of Disease-10 codesweighted surveyed population of adults, 3,564,763 (1.4%) had AF
- Participants
- 248,067,064 adults
- Exposure
- Incremental AF expenditures for the entire population and for individuals with common coexisting comorbidities
- AFn = 3,564,763
- Outcome
- Mean unadjusted annual total healthcare expenditure
Methodological detailsMedical Expenditure Panel Survey 2016 to 2021 data, 2-part and gamma regression models
- Medical Expenditure Panel Survey 2016 to 2021 data
- 2-part and gamma regression models
Main finding
As reported in the abstract
AF
$25,451
mean · ± $1,100
Without AF
$9,254
mean · ± $82
Observational data: associations, not effects.
Further findings
Highest spending categories (AF)
- Inpatient visits
- $7,975 ± $733
- Prescriptions
- $6,505 ± $372
Change in AF expenditures over the study period
- AF expenditures increased over the study period
- 11.1%
Adjusted incremental annual expenditure attributable to AF
- Incremental annual expenditure per person
- $6,185
- After adjustment
Incremental AF expenditures by comorbidity
- Cancer (highest)
- $12,052 ($4,476-$19,627)
- Heart failure (not significant)
- $30 (-$7,660 to $7,716)
Characteristics associated with higher expenditures among AF individuals
- Cancer, modified Charlson Comorbidity Index of 1 or ≥2, chronic kidney disease, type 2 diabetes mellitus, chronic obstructive pulmonary disease, atherosclerotic cardiovascular disease, poor income level, bachelor's degree, and later survey year were associated with higher expenditures
Characteristics of AF individuals
- Mean age
- 71.9 ± 10.6 years
- Female
- 45.7%
Original publication
Healthcare Expenditure on Atrial Fibrillation in the United States: The Medical Expenditure Panel Survey 2016 to 2021. JACC Adv. Published 25 April 2025. doi:10.
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