Heart failure & cardiomyopathies
Heart Failure in First- and Second-Generation Immigrants Aged 18–54 Years in Sweden: A National Study
Authors' conclusion
The fact that almost all increased risks were attenuated and absent in second-generation immigrants suggests that lifestyle and environmental factors are more important than genetic differences in the risk of CHF.
Study context
- Population
- Individuals aged 18–54 years in Sweden
- Participants
- 3,973,454 vs 3,817,560
- Exposure
- First- and second-generation immigrants vs Swedish-born
- Foreign-bornn = 3,973,454
- Second-generationn = 3,817,560
- Outcome
- Incident CHF (≥1 registered diagnosis in the National Patient Register)
- Follow-up
- 1 January 1998 to 31 December 2018
Methodological detailsnational register-based
- National register-based
Main finding
As reported in the abstract
Incident CHF
Hazard ratio (99% CI)
Foreign-born menfully adjusted; first-generation study
1.12(1.06–1.17)
Foreign-born womenfully adjusted; first-generation study
0.99(0.92–1.05)
Second-generation menfully adjusted; second-generation study
1.04(0.99–1.09)
Second-generation womenfully adjusted; second-generation study
0.97(0.90–1.04)
- Congestive heart failure (CHF) cases, first-generation study (54 369 men, 31 350 women)
- 85 719
- CHF cases, second-generation study (58 403 men, 30 596 women)
- 88 999
Observational data: associations, not effects.
Further findings
CHF by region of origin (first generation)
- Higher risk in men from Eastern Europe, Central Europe, Africa and Asia and women from Africa and Asia
- Lower risk among Latin American women
Original publication
Heart Failure in First- and Second-Generation Immigrants Aged 18–54 Years in Sweden: A National Study. ESC Heart Fail. Published 24 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →