Heart Failure in Patients with Congenital Heart Disease After a Cancer Diagnosis
Authors' conclusion
CHD patients face a more than four-fold increased risk of developing HF after a cancer diagnosis compared with cancer patients without CHD. Among CHD patients, the risk of HF is only modestly higher for those with cancer than for those without cancer.
Study context
- Population
- Individuals with and without congenital heart disease (CHD) born in Sweden 1952–2017 (excluding syndromes and transplant recipients)two matched cohorts
- Participants
- 1,232 / 2,602 / 2,257
- Exposure
- CHD patients with cancer vs non-CHD patients with cancer, and vs CHD patients without cancer
- CHD with cancern = 1,232
- Non-CHD with cancern = 2,602reference
- CHD without cancern = 2,257reference
- Outcome
- Heart failure (HF) after cancer diagnosis
Methodological detailspropensity-score matched, nationwide Swedish registers
- Propensity-score matched
- Nationwide Swedish registers
Main finding
As reported in the abstract
Hazard ratio (95% CI)
CHD with cancervs Non-CHD with canceradjusted for age at cancer diagnosis and comorbidities
4.39(2.83–6.81)
CHD with cancervs CHD without cancer
1.53(1.13–2.07)
Observational data: associations, not effects.
Original publication
Heart Failure in Patients with Congenital Heart Disease After a Cancer Diagnosis. ESC Heart Fail. Published 6 July 2024. doi:10.
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