Survival After Cardiac Transplantation in Adults With Single-Ventricle Congenital Heart Disease
Corrected 23 Oct 2026: Measure wording clarified; no values changed.
Authors' conclusion
Among adult CHD transplant recipients, single-ventricle physiology correlated with higher short-term mortality. However, 10-year conditional survival was similar for biventricular and most single-ventricle CHD patients, and notably better for biventricular CHD patients compared to non-CHD heart transplant recipients.
Study context
- Population
- Adults (≥18 years) with congenital heart disease (CHD) undergoing heart transplantation, 2005–2020
- Participants
- 382 CHD recipients
- Exposure
- Single-ventricle vs biventricular CHD heart transplant recipients
- Single-ventriclen = 185
- Outcome
- Survival after heart transplantation
- Follow-up
- 1 and 10 years
Methodological detailsoutcome-blinded investigators, probability-linkage of National Inpatient Sample and OPTN data sets
- Outcome-blinded investigators
- Probability-linkage of National Inpatient Sample and OPTN data sets
Main finding
As reported in the abstract
Survival
Single-ventricle
- 1-year survival
- 80%
- 10-year survival
- 54%
Biventricular CHD
- 1-year survival
- 91%
- 10-year survival
- 71%
1-year survival
Single-ventricle80%
Biventricular CHD91%
10-year survival
Single-ventricle54%
Biventricular CHD71%
Single-ventricle vs Biventricular CHDHazard ratio (95% CI)P value
1 year
2.50(1.40–4.49), event not clearly stated
P = 0.00210 years
2.10(1.38–3.18), event not clearly stated
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | Single-ventricle | Biventricular CHD | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| 10-year conditional survival (1-year survivors), biventricular vs single-ventricle | 71% | 79% | 1.58 (0.85–2.92) | P = 0.15 | |
| 10-year conditional survival, biventricular CHD vs non-CHD recipients | Not reported in the abstract | 79% | 0.73 (0.59–0.90) | P = 0.003 | Single-ventricle: not reported in the abstract |
| 0.20.5125Hazard ratio (log scale) |
- 10-year conditional survival, biventricular CHD vs non-CHD recipients: Non-CHD 68%
10-year conditional survival (1-year survivors), biventricular vs single-ventricle
- Similar except vs hypoplastic left heart syndrome
Original publication
Survival After Cardiac Transplantation in Adults With Single-Ventricle Congenital Heart Disease. J Am Coll Cardiol. Published 19 September 2023. doi:10.
Summarised from the published abstract; every number is checked against it