Heart failure & cardiomyopathies
Heart Failure With Preserved Ejection Fraction Across the Spectrum of Body Mass Index: Hemodynamic and Echocardiographic Characteristics and Outcomes
Authors' conclusion
In these large, real-world, multicenter analyses, higher BMI was associated with adverse hemodynamic and structural cardiac changes, a linear increase in the risk of HF hospitalization, and a stable risk of death.
Study context
- Population
- Patients with diagnosed heart failure with preserved ejection fraction (HFpEF) in PCORnet, 2012–2018, who had undergone echocardiography or invasive right heart catheterization
- Participants
- 149,027 patients
- Exposure
- Body mass index (BMI) categories
- Outcome
- Echocardiographic and hemodynamic measures; risk of HF hospitalization and death
- Follow-up
- Median 3.5 years
Methodological detailsmulticentre, registry
- Multicentre
- Registry
Main finding
As reported in the abstract
- Higher BMI associated with larger left atrial diameter, LV end-diastolic diameter, and higher mean pulmonary artery pressure and pulmonary capillary wedge pressure
- P < 0.001 for all
Observational data: associations, not effects.
Original publication
Heart Failure With Preserved Ejection Fraction Across the Spectrum of Body Mass Index: Hemodynamic and Echocardiographic Characteristics and Outcomes. JACC Heart Fail. Published 19 November 2025. doi:10.
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