Heart failure & cardiomyopathies
Prognostic Implications of Left Atrial Stiffness Index in Heart Failure Patients With Preserved Ejection Fraction
Main finding · Death or HF hospitalizationResult — go to the resultHazard ratio 1.59 95% CI 1.01–2.51Authors' conclusion
Increased LA stiffness was associated with increased risk for all-cause mortality and hospitalization caused by heart failure in patients who have HFpEF, and its prognostic role was more pronounced than that of indexes of left ventricular filling pressure.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF): elevated LV end-diastolic pressure (≥16 mm Hg) on left heart catheterization and preserved EF (≥50%), 2004–2019analysed with suitable peak atrial longitudinal strain (PALS) image quality
- Participants
- 307 patients
- Exposure
- High vs low left atrium (LA) stiffness index
- Low LA stiffnessn = 178reference
- High LA stiffnessn = 129
- Outcome
- Composite of:
- Mortality
- HF hospitalization
- Follow-up
- Median 6 years
Main finding
Death or HF hospitalization
Hazard ratio
1.59
95% CI 1.01–2.51
P = 0.044
LA stiffness index
HR 1.59 (95% CI 1.01–2.51); P = 0.044
As reported in the abstract
Observational data: associations, not effects.
Further findings
Correlations of LA stiffness index
- E/e' (r)
- 0.737
- LA volume index (r)
- 0.529
- RV systolic pressure (r)
- 0.404
- Log NT-proBNP (r)
- 0.540
- All P < 0.001
Predictive performance vs echocardiographic diastolic parameters
- LA stiffness index better than echocardiographic diastolic parameters
- P < 0.001
Original publication
Prognostic Implications of Left Atrial Stiffness Index in Heart Failure Patients With Preserved Ejection Fraction. JACC Cardiovasc Imaging. Published 11 January 2023. doi:10.
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