Heart Transplant and Pregnancy: Evaluating the Role of Preeclampsia in Maternal, Neonatal, and Graft Morbidity
Authors' conclusion
There was no difference in graft loss from delivery in HTRs who developed preeclampsia during pregnancy. Regardless of preeclampsia, pregnant HTRs are more likely than the general population to experience severe maternal morbidity.
Study context
- Population
- Adult heart transplant recipients with pregnancy outcomes ≥20 weeks' gestation, Transplant Pregnancy Registry International, 1986–2022
- Participants
- 146 pregnancies
- Exposure
- Preeclampsia vs no preeclampsia
- Preeclampsian = 42
- Outcome
- Graft loss
- Follow-up
- Within 2 years from delivery
Methodological detailsregistry-based
- Registry-based
Main finding
Graft loss at 2 years
Adjusted hazard ratio
0.79
95% CI 0.37–1.69
P = 0.54
By group
Preeclampsiavs No preeclampsia
adjusted HR 0.79 (95% CI 0.37–1.69); P = 0.54
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Gestational age at birth
P < 0.01
Birth weight
P < 0.01
Safety
Severe maternal morbidity
Original publication
Heart Transplant and Pregnancy: Evaluating the Role of Preeclampsia in Maternal, Neonatal, and Graft Morbidity. JACC Heart Fail. Published March 2025. doi:10.
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