Heart failure & cardiomyopathies
Heart Transplantation Outcomes with Donation After Circulatory Death in Patients with Left Ventricular Assist Device
Main finding · Short-term post-HT mortalityResult — go to the resultAdjusted hazard ratio 1.00 95% CI 0.70–1.42Authors' conclusion
In LVAD patients who received DCD HT, early post-transplant survival, stroke, acute kidney injury and length of stay were not significantly different from those who underwent DBD HT.
Study context
- Population
- Adults with left ventricular assist device (LVAD) listed for heart transplantation (HT), 17 October 2018 to 3 July 202489% DBD
- Participants
- 3,336 adults
- Exposure
- DCD HT vs DBD HT in LVAD patients
- Outcome
- Survival
- Follow-up
- First year post-HT
Methodological detailsUNOS registry
- UNOS registry
Main finding
Short-term post-HT mortality
Adjusted hazard ratio
1.00
95% CI 0.70–1.42
P > 0.9
DCDvs DBD
aHR 1.00 (95% CI 0.70–1.42); P > 0.9
As reported in the abstract
Observational data: associations, not effects.
Further findings
Transplantation within 1 year at centres performing DCD
| aHR (95% CI) | P value | ||
|---|---|---|---|
| DCD centres | 1.44 (1.39–1.49) | P < 0.001 | |
| 0.512Adjusted hazard ratio (log scale) |
In-hospital stroke and AKI requiring dialysis
- Not different from DBD-HT
Safety
| Outcome | aRR (95% CI) | P value | |
|---|---|---|---|
| Primary graft dysfunction | 3.8 (2.5–5.7) | P < 0.001 | |
| Treated rejection | 1.48 (1.14–1.93) | P = 0.003 | |
| 0.20.5125Adjusted relative risk (log scale) |
Original publication
Heart Transplantation Outcomes with Donation After Circulatory Death in Patients with Left Ventricular Assist Device. ESC Heart Fail. Published 26 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →