Hemodialysis and its impact on patient characteristics, microbiology, cardiac surgery, and mortality in infective endocarditis
Authors' conclusion
Patients with IE on chronic hemodialysis were younger, had more comorbidity, a higher prevalence of Staphylococcus aureus IE, and a higher mortality than patients without hemodialysis.
Study context
- Population
- Patients with infective endocarditis, Denmark, February 1, 2010 to May 14, 2018
- Participants
- 4,366 patients
- Exposure
- Hemodialysis vs non-hemodialysis in infective endocarditis
- Hemodialysisn = 226
- Outcome
- Mortality
Methodological detailsDanish nationwide registries, multivariable Cox regression
- Danish nationwide registries
- Multivariable Cox regression
Main finding
As reported in the abstract
Hemodialysis
- In-hospital mortality
- 20.8%
- 1-year mortality
- 37.7%
- 5-year mortality
- 72.1%
Non-hemodialysis
- In-hospital mortality
- 18.5%
- 1-year mortality
- 17.7%
- 5-year mortality
- 42.5%
In-hospital mortality
Hemodialysis20.8%
Non-hemodialysis18.5%
1-year mortality
Hemodialysis37.7%
Non-hemodialysis17.7%
5-year mortality
Hemodialysis72.1%
Non-hemodialysis42.5%
Hemodialysis vs Non-hemodialysisHazard ratio (95% CI)
1-year mortality, adjusted
2.71(2.07–3.55)
5-year mortality, adjusted
2.72(2.22–3.34)
Observational data: associations, not effects.
Further findings
Age
Surgical treatment
In-hospital mortality
Staphylococcus aureus infective endocarditis (IE) prevalence
- Staphylococcus aureus more than twice as prevalent with hemodialysis than without (58.0% vs 26.5%)
In-hospital mortality
- No difference between the 2 groups
Original publication
Hemodialysis and its impact on patient characteristics, microbiology, cardiac surgery, and mortality in infective endocarditis. Am Heart J. Published 3 June 2023. doi:10.
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