Hepatic Tissue Alterations in ST-Elevation Myocardial Infarction: Determinants and Prognostic Implications
Authors' conclusion
Hepatic tissue alterations determined by T1 mapping were associated with female sex, hyperlipidemia, multivessel disease, N-terminal pro-B-type natriuretic peptide, and left and RV myocardial tissue damage. These alterations can persist into the chronic phase after STEMI and indicate a worse clinical outcome.
Study context
- Population
- Patients with STEMI treated with PCI, enrolled in the prospective MARINA STEMI study
- Participants
- 485 patients
- Outcome
- Associations of hepatic T1 patterns with myocardial tissue damage and clinical outcomes (MACE)
Methodological detailsCMR within first week after STEMI; hepatic T1 and extracellular volume from standard cardiac T1 maps at baseline and 4 months
- CMR within first week after STEMI; hepatic T1 and extracellular volume from standard cardiac T1 maps at baseline and 4 months
Main finding
As reported in the abstract
Hepatic T1 times
- Median hepatic T1 time at baseline, ms (IQR 514-605)
- 559
- Median hepatic T1 time at 4 months, ms (IQR 507-577); decrease from baseline P<0.001
- 542
- Baseline T1 associated with female sex (P=0.008)
- β 0.116
- Baseline T1 associated with hyperlipidemia (P=0.008)
- β −0.116
- Baseline T1 associated with infarct size (P<0.001)
- β 0.178
- Baseline T1 associated with microvascular obstruction (P<0.001)
- β 0.193
- Baseline T1 associated with right ventricular (RV) infarction (P<0.001)
- β 0.161
- 4-month T1 associated with female sex (P=0.002)
- β 0.123
- 4-month T1 associated with multivessel disease (P=0.002)
- β 0.121
- 4-month T1 associated with NT-proBNP (P=0.010)
- β 0.101
- 4-month T1 associated with RV infarction (P<0.001)
- β 0.501
- 4-month T1 associated with RV end-systolic volume index (P=0.031)
- β 0.087
- MACE, patients without vs with T1 decrease (P=0.003)
- 13% versus 5%
- Baseline hepatic T1 and MACE, HR
- 1.87 (95% CI 1.40-2.50; P<0.001)
- 4-month hepatic T1 and MACE, HR
- 2.69 (95% CI 2.15-3.36; P<0.001)
- 4-month hepatic extracellular volume and MACE, HR
- 1.59 (95% CI 1.33-1.90; P<0.001)
- After adjustment, only 4-month hepatic T1 independently associated with adverse outcomes, HR
- 2.86 (95% CI 1.99-4.12; P<0.001)
Observational data: associations, not effects.
Original publication
Hepatic Tissue Alterations in ST-Elevation Myocardial Infarction: Determinants and Prognostic Implications. Circ Cardiovasc Imaging. Published 29 November 2024. doi:10.
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