Association of Circulating PCSK9 With Ischemia-Reperfusion Injury in Acute ST-Elevation Myocardial Infarction
Authors' conclusion
In patients with STEMI, a significant increase in PCSK9 was observed from 24 to 48 hours after PCI. While PCSK9 levels after 24 hours were not related to myocardial or microvascular injury, PCSK9 after 48 hours was significantly associated with intramyocardial hemorrhage, MVO, and infarct size as well as worse subsequent clinical outcomes.
Study context
- Population
- Patients with ST-elevation myocardial infarction (STEMI) revascularised by primary percutaneous coronary intervention (PCI)
- Participants
- 205 patients
- Exposure
- PCSK9 levels by presence vs absence of CMR-visualised ischaemia-reperfusion injury
- Outcome
- Presence of intramyocardial hemorrhage (CMR T2* mapping)
Methodological detailsprespecified substudy of the MARINA-STEMI registry, PCSK9 measured by immunoassay 24 and 48 h after PCI
- Prespecified substudy of the MARINA-STEMI registry
- PCSK9 measured by immunoassay 24 and 48 h after PCI
Main finding
As reported in the abstract
P = 0.004
- PCSK9 at 24 h after PCI not related to intramyocardial hemorrhage, microvascular obstruction (MVO) or infarct size
- all P>0.05
Observational data: associations, not effects.
Further findings
MVO vs No MVO
PCSK9 at 48 h by MVO
P = 0.020
Large infarct size vs Smaller infarct size
PCSK9 at 48 h by infarct size
P = 0.013
PCSK9 >361 ng/mL vs PCSK9 ≤361 ng/mL
Major adverse cardiac events by PCSK9 at 48 h · median follow-up 12 months
P = 0.002
Change in PCSK9 from 24 to 48 h after PCI
- Significant increase in PCSK9 (ng/mL)
- 268-304 ng/mL; P<0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →