Heterogeneity of coronary vascular function and myocardial oxygenation in women with angina and non-obstructive coronary artery disease
Authors' conclusion
Heterogeneous myocardial oxygenation may explain ischaemic symptoms without any associated epicardial obstructive coronary artery disease.
Study context
- Population
- Women aged 40–65 years with persistent retrosternal chest pain and ANOCA, or without CVD history
- Exposure
- Women with ANOCA vs healthy controls
- ANOCAn = Fifty-four
- Healthy controlsn = 48reference
- Outcome
- Myocardial oxygenation (global and regional heterogeneity) by breathing-enhanced OS-CMR
Methodological details2 sites in Canada
- 2 sites in Canada
Further findings
| Outcome | ANOCA | Healthy controls | P value |
|---|---|---|---|
| Global myocardial oxygenation (%Δ in SI) | mean 4.9 (SD ±7.3) %Δ in SI | mean 4.5 (SD ±10.1) %Δ in SI | P = 0.82 |
| Regional variation in myocardial oxygenation, circumferential (%Δ in SI)Remained present in a multivariate model | median 5.1 (IQR 2.0–7.6) %Δ in SI | median 2.2 (IQR 1.4–3.5) %Δ in SI | P = 0.0004 |
| Regional variation in myocardial oxygenation, longitudinal (%Δ in SI)Remained present in a multivariate model | median 11.4 (IQR 5.4–16.7) %Δ in SI | median 6.0 (IQR 3.0–7.0) %Δ in SI | P = 0.001 |
Global myocardial oxygenation (%Δ in signal intensity (SI))
- No significant difference in volume, function, mass or global myocardial oxygenation
Original publication
Heterogeneity of coronary vascular function and myocardial oxygenation in women with angina and non-obstructive coronary artery disease. Eur Heart J Cardiovasc Imaging. Published 28 March 2024. doi:10.
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