The prognostic value of visual and automatic coronary calcium scoring from low-dose computed tomography-[15O]-water positron emission tomography
Authors' conclusion
There is a moderate agreement in risk classification between visual and automatic CAC scoring from LDCT and reference CSCT scans. Visual and automatic CAC scoring from LDCT scans improve identification of patients at higher risk of MACE.
Study context
- Population
- Consecutive patients with suspected CAD undergoing [15O]-water PET myocardial perfusion imaging (MPI) with LDCT and dedicated calcium scoring CT (CSCT)
- Participants
- 572 patients
- Comparison
- Visual and automatic (deep learning) coronary artery calcium (CAC) scoring on LDCT vs manual CAC scoring on dedicated CSCT
- Outcome
- Agreement in CAC risk group classification (0, 1-100, 101-400, 401-1000, >1000) between LDCT and reference CSCT; added value of LDCT CAC for prediction of MACE
Methodological detailsconsecutive patients
- Consecutive patients
Performance
As reported in the abstract
Agreement in risk group classification vs reference CSCT
LDCT visual
0.66
95% CI 0.62–0.70
LDCT automatic
0.58
95% CI 0.53–0.62
Further findings
Major adverse cardiac events (MACE) (all-cause death, non-fatal MI, coronary revascularization, unstable angina)
- Increased MACE risk with CAC > 100 on visual LDCT scoring and CAC > 400 on automatic LDCT scoring, independent of ischaemic information from PET
Original publication
The prognostic value of visual and automatic coronary calcium scoring from low-dose computed tomography-[15O]-water positron emission tomography. Eur Heart J Cardiovasc Imaging. Published 26 March 2024. doi:10.
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