Arrhythmias & electrophysiology
High-Frequency Low-Tidal Volume Ventilation Improves Long-Term Outcomes in AF Ablation: A Multicenter Prospective Study
Authors' conclusion
HFLTV ventilation during catheter ablation of PAF improved freedom from all-atrial arrhythmia recurrence, AF-related symptoms, and AF-related hospitalizations with shorter procedural times.
Study context
- Population
- Patients undergoing radiofrequency (RF) ablation of paroxysmal AF (REAL-AF registry)
- Participants
- 661 patients
- Exposure
- High-frequency, low-tidal-volume (HFLTV) ventilation vs standard ventilation during RF ablation
- HFLTVn = 216
- Standard ventilation (SV)n = 445reference
- Outcome
- Freedom from all-atrial arrhythmia
- Follow-up
- 12 months
Main finding
As reported in the abstract
| Group | Value | Denominator |
|---|---|---|
| HFLTV | 85.6% | 216 |
| SV | 79.3% | 445 |
Value
HFLTV85.6%
SV79.3%
Denominator
HFLTV216
SV445
- HFLTV vs SV: P = 0.041
- Absolute reduction in all-atrial arrhythmia recurrence with HFLTV (printed "HLTV")
- 6.3%
Observational data: associations, not effects.
Secondary outcomes
Procedural time
P < 0.001
Total RF time
P < 0.001
PV RF time
P < 0.001
First-pass PV isolation
P = 0.036
AF-related symptoms · 12 months
- Lower rate of AF-related symptoms with HFLTV (printed "HLTV"): 12.5% vs 18.9%
- P = 0.046
Hospitalizations · 12 months
- Lower rate of hospitalizations with HFLTV (printed "HLTV"): 1.4% vs 4.7%
- P = 0.043
Safety
- No significant difference in the rate of complications
Original publication
High-Frequency Low-Tidal Volume Ventilation Improves Long-Term Outcomes in AF Ablation: A Multicenter Prospective Study. JACC Clin Electrophysiol. Published 18 May 2023. doi:10.
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