High-Risk Plaques on Coronary Computed Tomography Angiography: Correlation With Optical Coherence Tomography
Authors' conclusion
All 4 HRP features on CTA were associated with features of vulnerability on OCT.
Study context
- Population
- Patients who underwent both computed tomography angiography (CTA) and optical coherence tomography (OCT) before coronary intervention1,075 lesions analysed
- Participants
- 448 patients
- Exposure
- High-risk plaque (HRP) features on CTA vs plaque characteristics on OCT
- Outcome
- Correlation of HRP features on CTA with plaque characteristics on OCT
Methodological detailsCTA vs OCT correlation, follow-up up to 3 years
- CTA vs OCT correlation
- Follow-up up to 3 years
Main finding
As reported in the abstract
HRP features on CTA vs OCT vulnerability features
- All 4 HRP features associated with thin-cap fibroatheroma
- Positive remodeling (PR) associated with all OCT features of plaque vulnerability
- Low-attenuation plaque (LAP) associated with lipid-rich plaque, macrophage and cholesterol crystals
- Napkin-ring sign (NRS) associated with cholesterol crystals
- Spotty calcification (SC) associated with microvessels
Observational data: associations, not effects.
Further findings
Composite of target vessel nontarget lesion revascularization and cardiac death (cumulative incidence) · up to 3 years
P = 0.010
Original publication
High-Risk Plaques on Coronary Computed Tomography Angiography: Correlation With Optical Coherence Tomography. JACC Cardiovasc Imaging. Published 13 September 2023. doi:10.
Summarised from the published abstract; every number is checked against it