Higher Noncalcified Plaque Volume Is Associated With Increased Plaque Vulnerability and Vascular Inflammation
Authors' conclusion
Higher NCP volume was associated with higher plaque vulnerability and vascular inflammation.
Study context
- Population
- Patients undergoing preintervention coronary CT angiography and optical coherence tomography704 plaques
- Participants
- 454 patients
- Exposure
- High vs low noncalcified plaque (NCP) volume
- Outcome
- Plaque vulnerability (optical coherence tomography) and vascular inflammation (PCAT attenuation) by NCP volume
Main finding
As reported in the abstract
Lipid-rich plaque
Thin-cap fibroatheroma
Macrophage
Microvessel
Cholesterol crystal
Observational data: associations, not effects.
Further findings
| Outcome | High NCP volume | Low NCP volume | P value |
|---|---|---|---|
| PCAT attenuation | −69.6 (SD 10.0) Hounsfield unit | −73.5 (SD 10.6) Hounsfield unit | P < 0.001 |
Multivariable analysis
- NCP volume significantly associated with thin-cap fibroatheroma and high pericoronary adipose tissue (PCAT) attenuation
Thin-cap fibroatheroma by PCAT attenuation and NCP volume combination
- Highest with high PCAT attenuation and high NCP volume; lowest with low PCAT attenuation and low NCP volume
Original publication
Higher Noncalcified Plaque Volume Is Associated With Increased Plaque Vulnerability and Vascular Inflammation. Circ Cardiovasc Imaging. Published 11 January 2024. doi:10.
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