Heart failure & cardiomyopathies
How Does Age Affect Outcomes After Left Ventricular Assist Device Implantation: Results from the PCHF-VAD Registry
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.34 95% CI 1.15–1.57Authors' conclusion
In the PCHF-VAD registry, higher age was associated with increased risk of mortality, and especially with increased risk of major bleeding, which is particularly relevant for the DT population.
Study context
- Population
- Patients with continuous-flow LVAD (cf-LVAD) implantation, PCHF-VAD registry
- Participants
- 562 patients
- Exposure
- Age categories <50 vs 50-64 vs ≥65 years
- <50n = 184
- 50-64n = 305
- ≥65n = 73
- Outcome
- All-cause mortality
- Follow-up
- Median 1.1 years
Methodological detailsmulticentre, European registry
- Multicentre
- European registry
Main finding
As reported in the abstract
Hazard ratio
1.34
95% CI 1.15–1.57
10 year increase in age
HR 1.34 (95% CI 1.15–1.57)
Observational data: associations, not effects.
Secondary outcomes
Designation as destination therapy (DT) candidate
- Oldest age group significantly more often designated DT candidates
- 61%
Device-related infections requiring systemic antibiotics
- Older patients had fewer device-related infections requiring systemic antibiotics
Heart failure (HF) hospitalizations, ventricular arrhythmias, pump thrombosis, non-fatal thromboembolic events, right ventricular (RV) failure
- No age-related differences
Safety
| Outcome | HR (95% CI) | |
|---|---|---|
| Intracranial bleeding | 1.49 (1.10–2.02) | |
| Non-intracranial bleeding | 1.30 (1.09–1.56) | |
| 0.512Hazard ratio (log scale) |
Haemocompatibility score
- Higher mean haemocompatibility score, oldest vs youngest groups: 1.37 vs 0.77
- P = 0.033
Original publication
How Does Age Affect Outcomes After Left Ventricular Assist Device Implantation: Results from the PCHF-VAD Registry. ESC Heart Fail. Published 2 December 2022. doi:10.
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