Heart failure & cardiomyopathies
Red Cell Distribution Width as a Prognosticator in Patients with Heart Failure
Authors' conclusion
Increased RDW at the time of diagnosis is associated with poor prognosis in patients with HF, independent of clinical risk factors, such as NT-proBNP, and echocardiographic parameters.
Study context
- Population
- Patients with heart failure (HF) (ejection fraction (EF) < 50% or HFA-PEFF score ≥ 2) without severe valvular heart disease or coronary revascularization, 3 referral hospitals, 2010–2021
- Participants
- 6,599 patients
- Exposure
- Elevated RDW vs non-elevated RDW
- Outcome
- All-cause mortality
- Follow-up
- Median 887 (IQR 351-1589) days
Methodological detailsmulticentre (3 referral hospitals), stabilized inverse probability of treatment weighting (IPTW)
- Multicentre (3 referral hospitals)
- Stabilized IPTW
Main finding
As reported in the abstract
Elevated RDW vs Non-elevated RDWEstimate (95% CI)P value
Cumulative incidence; log-rank P
RR 1.58(1.51–1.67)
P < 0.001Multivariable Cox, independent of clinical risk factors, NT-proBNP and EF
HR 1.11(1.06–1.16)
P < 0.001Stabilized IPTW
HR 1.29(1.10–1.49)
P < 0.001Observational data: associations, not effects.
Further findings
Incremental prognostic value of adding RDW to model of traditional risk factors, N-terminal pro-brain natriuretic peptide (NT-proBNP) and echocardiographic parameters
- AUC
- 0.799-0.826
- P
- P < 0.001
Original publication
Red Cell Distribution Width as a Prognosticator in Patients with Heart Failure. ESC Heart Fail. Published 2 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →